Trifluoperazine dihydrochloride
CAS No. 440-17-5
Trifluoperazine dihydrochloride( TFP | SKF5019 )
Catalog No. M14498 CAS No. 440-17-5
An antiadrenergic, antidopaminergic and anticholinergic agent.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
100MG | 45 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameTrifluoperazine dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionAn antiadrenergic, antidopaminergic and anticholinergic agent.
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DescriptionAn antiadrenergic, antidopaminergic and anticholinergic agent; is identified as an inhibitor that disrupts the S100A4/myosin-IIA interaction; block S100A4-mediated disassembly of myosin-IIA filaments, and promote S100A4 oligomerization.Schizophrenia Approved(In Vitro):Trifluoperazine dihydrochloride is a long-established, widely used 'conventional' antipsychotic agent. Trifluoperazine dihydrochloride has been an extensively studied drug molecule that has been used as a calmodulin inhibitor.Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis, but not budding, by disturbing cellular CaM and/or CaM-dependent functions.
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In VitroTrifluoperazine dihydrochloride is a long-established, widely used 'conventional' antipsychotic agent. Trifluoperazine dihydrochloride has been an extensively studied drug molecule that has been used as a calmodulin inhibitor.Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis, but not budding, by disturbing cellular CaM and/or CaM-dependent functions.
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In Vivo——
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SynonymsTFP | SKF5019
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorD2
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number440-17-5
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Formula Weight480.4174
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Molecular FormulaC21H26Cl2F3N3S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESFC(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F.[H]Cl.[H]Cl
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Chemical Name10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, hydrochloride (1:2)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Malashkevich VN, et al. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8605-10.
2. Huerta-Bahena J, et al. Mol Pharmacol. 1983 Jan;23(1):67-70.
3. Creese I, et al. J Neuropsychiatry Clin Neurosci. 1996 Spring;8(2):223-6.
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